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DeCS
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Descriptor English:
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Methylenetetrahydrofolate Dehydrogenase (NADP)
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Descriptor Spanish:
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Metilenotetrahidrofolato Deshidrogenasa (NADP)
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Descriptor Portuguese:
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Metilenotetra-Hidrofolato Desidrogenase (NADP)
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Synonyms English:
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Dehydrogenase, Methylenetetrahydrofolate
Methylenetetrahydrofolate Dehydrogenase
Methylenetetrahydrofolate Dehydrogenase (NADP+)
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Tree Number:
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D08.811.682.662.253
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Definition English:
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An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE. |
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Indexing Annotation English:
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do not confuse with METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NAD+)
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See Related English:
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Formate-Tetrahydrofolate Ligase
Methenyltetrahydrofolate Cyclohydrolase
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History Note English:
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2004(1975);
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Allowable Qualifiers English:
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Record Number:
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8940
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Unique Identifier:
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D008754
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Occurrence in VHL:
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Similar:
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DeCS
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